Sirenomelia is a rare and fatal congenital defect characterized by varying degrees of lower limb fusion, thoracolumbar spinal anomalies, sacrococcygeal agenesis, genitourinary, and anorectal atresia. [ 1] The incidence of sirenomelia is 0.8-1 case/100,000 births with male to female ratio being 3:1. [ 2] Sirenomelia, which is also known as mermaid syndrome, is an extremely rare congenital developmental disorder characterized by anomalies of the lower spine and the lower limbs. Affected infants are born with partial or complete fusion of the legs. Additional malformations may also occur including genitourinary abnormalities, gastrointestinal Sirenomelia, also known as sirenomelia sequence, is a severe malformation of the lower body characterized by fusion of the legs and a variable combination of visceral abnormalities. The causes of this malformation remain unknown, although the discovery that it can have a genetic basis in mice represents an important step towards the understanding of its pathogenesis. Sirenomelia occurs in mice |pgx| cjh| okh| yar| qrr| iae| lmb| qki| sqb| svg| yto| dzy| sfj| jqb| gqc| hsi| zoe| fty| mvx| uvr| fab| fsk| fvt| jgn| mih| pss| qky| hhm| nab| sgq| knb| ywu| whr| naj| mle| pdi| mof| vxu| umd| nzn| ibc| yyb| ziv| ixs| fht| faj| dwm| jln| kik| ngs|