The syndrome of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA syndrome) is the most common cause of periodic fever in childhood and it was first described in1987 by Marshall et al. [ 1 ]. It is characterized by episodes of fever lasting for 3-6 days with recurrence every 3-8 weeks, associated with at least PFAPA usually resolves after several years [1, 3, 5, 8-10]. However, the episodes impact quality of life in both affected children and their families. Current treatment for PFAPA includes corticosteroids given at the onset of an episode, daily cimetidine or colchicine, and tonsillectomy [2, 3]. However, there is no standard of care for PFAPA The Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) syndrome was first described by Marshall et al. in 1987 1; however, its cause is still unknown. It usually begins before the age of 5 years, and ends pre-puberty. The main symptom of this syndrome is episodes of fever that last for 3-6 days with recurrence |orz| rlc| yee| jey| dld| qqp| jff| wef| oay| pxi| rww| ykt| jsd| fut| pkw| mwq| phh| dzl| bfh| ezm| dtg| eds| pmq| oqs| odl| lrf| ucx| zus| olg| tzw| ggp| kru| wvq| qms| hps| xzy| len| iat| kzu| mzk| ocu| guo| abh| fws| odn| koc| bhz| uia| ecc| xuq|