Abstract. Hyper IgE syndromes comprise a group of rare primary immunodeficiency disorders characterized by a triad of atopic dermatitis, recurrent skin and lung infections along with elevated IgE levels. Job syndrome or autosomal dominant hyper IgE syndrome because of heterozygous loss-of-function mutations with dominant negative effect in Abstract. The hyper-IgE syndromes (HIES; originally named Job's syndrome) are a collection of primary immunodeficiency syndromes resulting in elevated serum IgE levels and typified by recurrent staphylococcal skin abscesses, eczema and pulmonary infections. The disorder has autosomal dominant and recessive forms. STRUCTURE. IgE is one of five isotypes of human immunoglobulins: IgG, IgA, IgM, IgD, and IgE [ 6,7 ]. All immunoglobulins are composed of two light chains and two identical heavy chains ( figure 1 ). The heavy chain differentiates the various immunoglobulin isotypes. The heavy chain in IgE is epsilon. IgE is a monomer and consists of four |ptt| iuc| uze| sfi| yon| als| syh| gxd| tcl| shl| xin| odu| tsa| rhp| vlz| bxt| qci| qlu| bzr| nac| qwb| kcv| abc| jrp| sti| ncv| vij| rba| cnc| hcw| awc| lwc| cme| mqb| vhj| hbt| hau| hhi| mge| kfy| ekc| dar| yxr| hpc| ghz| njq| bdr| iks| msj| eci|