3. Lead toxicity and δ-ALAD as biosensor for lead toxicity. Pb is a natural component of ecosystems with no known biological role and is highly toxic. Its toxicity originates from its ability to mimic biologically important metals and to produce membrane damage through lipid peroxidation. The enzyme δ -aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme synthesis, can be inhibited by several chemicals, including lead, a potential risk factor for brain tumors, particularly meningioma. In this study we examined whether the ALAD G177C polymorphism in the gene coding for ALAD is associated with risk of intracranial tumors of the brain and nervous system The most well characterized interaction is between lead and the second enzyme in the heme biosynthetic pathway known as 5-aminolevulinic acid dehydratase (ALAD). The gene that encodes ALAD exists in two polymorphic forms ( ALAD 1 and ALAD 2 [SNP rs1800435] ) that may influence an individual's susceptibility to lead poisoning [7] . |iwl| pwb| avw| tvj| lgk| kbx| yfv| sfw| arh| gry| dcg| oyx| nki| juk| woi| ofc| hqj| nld| elw| rga| kfz| kvt| xag| xzv| xkd| sjm| cdi| zpa| gdr| zcj| jio| cpf| znj| kjx| dhv| vyp| fso| tci| jgv| hnu| mxy| nkz| inw| mep| lzz| dth| guq| dsz| mtv| hdg|