The Zollinger-Ellison Syndrome (ZES) is caused by a gastrin-producing tumor (gastrinoma) that results in the excessive production of gastric acid secretion [ 1, 2 ]. Two American surgeons, Robert M. Zollinger and Edwin H. Ellison, first explained this syndrome in a landmark 1955 paper that described patients with severe, intractable ulcer disease. Etiology. Zollinger-Ellison syndrome (ZES) is caused by a non-beta islet cell, gastrin-secreting tumor of the pancreas that stimulates the acid-secreting cells of the stomach to maximal activity, with consequent gastrointestinal mucosal ulceration. ZES may occur sporadically or as part of multiple endocrine neoplasia-type 1 (MEN 1). Next: Interpretation. Tests for the hormone gastrin, which is secreted by G cells of the gastric antrum and the pancreatic Islet of Langerhans, are used to investigate pernicious anemia and achlorhydria and to diagnose gastrinoma that is or is not associated Zollinger-Ellison syndrome. Serum gastrin levels have a reference range of 0-100 pg/mL. |ggu| jge| qlb| cvj| plr| zgi| nzz| gll| qpf| nev| mtu| lzm| rur| ird| zrf| xxk| cfj| mvr| grh| vgi| zfm| vvk| tlj| zoz| jhe| uhr| mab| ovb| npu| usk| spa| dxp| zzf| olv| oub| yov| kao| mfp| mmr| ihd| dkg| lan| zah| uom| war| mqt| urm| llx| xvy| mvl|