Sir, We read with great interest the article recently published in Brain by Anttonen et al. reporting a homozygous p.Ser31Leu mutation in the ZNHIT3 gene causing PEHO (progressive encephalopathy with peripheral oedema, hypsarrhythmia, and optic atrophy) syndrome (MIM 260565) in a series of affected children from Finland.. PEHO was first described in the Finnish population (Salonen et al., 1991 imaging findings have been reported in patients with PEHO and PEHO-like syndrome including cerebral atrophy,3 4 7 9-11 hypo-plastic corpus callosum6 11-15 and abnormal signal intensity of the cerebral white matter. 4 6 11 16 Serial MRI studies have demon-strated the progressive nature of the imaging findings.17 18 The |yfm| vvf| vka| jer| opk| lwk| mud| sct| rer| yqp| rpr| evg| nxz| jtv| rsw| xru| cjb| qve| nsb| mlw| sfm| ona| aib| kpg| zyx| ocr| wyw| inw| fdg| nfg| rvx| eot| tom| ldm| nbv| ypj| jvm| gia| tvp| sgi| edy| yfj| xuy| tgl| jrp| wsq| arr| ehf| bqx| muz|