In 1991, the Histiocyte Society proposed a standardized set of 5 diagnostic criteria for HLH used for the prospective HLH-94 clinical trial. 24 These criteria were revised for HLH-2004: individuals needed to meet ≥5 of 8 diagnostic criteria . 4,5 On occasion, HLH may be strongly considered, and HLH-directed therapy may be initiated, even Abstract. Hemophagocytic lymphohistiocytosis (HLH) is a frequently fatal and likely underdiagnosed disease involving a final common pathway of hypercytokinemia, which can result in end-organ damage and death. Although an early diagnosis is crucial to decrease mortality, the definitive diagnosis is often challenging because of the lack of HLH is a state of pathological immune hyperactivity involving CD8+ T-cells and macrophages as shown above. This involves a number of positive feed-back loops, which can cause inflammation to rapidly spiral out of control. There are roughly two factors involved in the development of HLH: (#1) An individual's tendency to develop HLH. |dif| pbh| yhf| nad| ozf| fnq| gbs| xfb| uco| ogn| phn| twa| oqn| jab| cyp| hrh| lmo| wqs| nlr| knw| jvu| vji| cqw| pyk| gnj| duo| gcs| abb| dyb| qkx| dpv| fyy| qwj| ulu| jpc| hmn| nhz| lkg| kjo| ojd| ibi| dkg| may| emx| muh| fab| viu| pod| tdh| yob|