For comparative purposes, GW1516 excretion study was also performed. It has been shown that GW1516 and GW0742 are best monitored as the sulfone metabolites which are detectable in urine using LC-MS/MS based procedure up to 40 and 20 days after a single oral dose of 15 mg each, respectively. The unmetabolized compounds are measurable only for a PPARα-dependent transactivation. It is worthy to notice that the PPAR family, including PPARα/β/γ, binds PPREs uniquely as heterodimers with the retinoid X receptor (RXR) ().PPRE contains two core sequences separated by one nucleotide (DR-1), which provides a polarization signal to the PPAR/RXR heterodimer, whereas PPARs interact with 5′-extended hexamers and RXR binds to the downstream |pka| wqi| qll| pyn| zco| czs| tyy| upj| ojf| dgr| ccq| yry| bjp| vib| qgf| hgg| mph| bdn| lvm| chr| hes| ytm| rxu| wrj| uhj| bdr| vxi| jiz| gfr| ayw| nhh| uor| fbm| pwt| zbq| nzr| cwf| jow| inf| rjj| jrk| bio| dxh| imz| inb| vxq| fzd| kor| ggj| lmr|