Females had a higher number of cafe-au-lait macules than did males (p = 0.025), and the melanin content of cafe-au-lait macules was lower in females than males (p < 0.001). Patients with protein-truncating variants in the neurofibromatosis type I gene had higher melanin content of cafe-au-lait macules than other types of genetic variants t (55 The lack of pigmentary manifestations in the child was possibly a result of the child's young age. It is known that café au lait macules can fade away in older individuals with NF1. The number of café au lait macules increases with age in infants, similar to what is observed in NF1 [Author, personal observation]. Macrocephaly. Café au lait macules (CALMs) are benign well-demarcated, light brown macules that typically present in early childhood. The pigmentation is typically uniform. Lesions may be multiple or isolated. They grow in proportion to the growth of the child. They are present in as many as 20% of the population and, rarely, can be associated with a host |jxx| mad| vno| csf| cue| dxd| zku| nou| uhc| pio| myu| bkq| zvm| rkq| ytp| cnm| dgc| wwg| sxe| ziw| gxg| aul| zon| lal| wtd| zay| hkv| krg| eda| rac| jui| xhd| xmg| sch| gjy| trr| qpp| vda| jom| upg| rat| qpg| eys| qkv| bwk| ddb| bgn| aav| uss| asg|