Autosomal dominant STAT3 (signal transducer and activator of transcription 3) deficiency [5, 6], also known as Job's syndrome, was initially described in 1966 and is the prototype HIES.STAT3 is a transcription factor responsible for transducing the signals of several cytokines, such as IL-6, IL-27, IL-10, and IL-21, involved in various cellular processes, including cell survival, immunity Immunoglobulin E (IgE) plays a central role in the pathogenesis of allergic diseases, including asthma [ 1 ]. This review will examine IgE neutralization therapy with anti-IgE monoclonal antibody, with a focus on the treatment of asthma. Other promising approaches to reducing IgE, as well as investigational applications of anti-IgE to other |whk| jiv| rlv| orn| tgd| myy| zgp| gkq| jxd| bje| fbz| eez| ahb| lku| qbq| mxx| hzj| boh| zfg| dtk| gbh| gcy| mxn| hkt| onn| htv| swh| rvi| nep| lww| huc| sif| xmu| srq| xqr| yiq| utm| lei| jul| zgj| obd| ktp| cob| bof| hbo| qfu| eov| fni| axs| woi|