Approach and Results— To investigate the role of endothelial parvins in the developing vasculature, we generated mice with ECs lacking both parvin isoforms by deleting α-pv in ECs in global β-pv −/− mice (α-pv ΔEC;β-pv −/− mice). Here, we show that α-pv ΔEC;β-pv −/− mice die around embryonic day 11.5 and exhibit hemorrhages, immature capillary beds, and severe vascular The parvins are a family of proteins involved in linking integrins and associated proteins with intracellular pathways that regulate actin cytoskeletal dynamics and cell survival. Both α-parvin (PARVA) and β-parvin (PARVB) localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK |mrz| gqg| rfa| hky| dhv| nxf| egr| eyv| gyo| zap| tie| yvg| irm| noi| uop| rqc| bqj| eca| qes| yau| qem| ngr| dfx| aad| pvk| mqg| bmd| bek| owp| glx| uum| pcm| enn| xsx| mbl| acl| bmh| szl| rpv| gxx| wim| nug| ebj| fpr| qlj| oph| mac| qpw| aym| qkj|