Normal T cell development in the thymus undergoes a major developmental checkpoint in which T cell receptor (TCR) signaling is involved. Thymocytes bearing TCR with a high affinity for self-peptide MHC complexes undergo apoptosis (negative selection), whereas those bearing low-affinity TCR survive and differentiate into mature T cells (positive 1）tcr のa鎖は，抗原ペプチドの左（n 末端側の）半 分とhla（mhc）の下側を認識する。 2）tcr のb鎖は，抗原ペプチドの右（c 末端側の）半 分とhla（mhc）の上側を認識する。 典型的なphla（mhc）複合体を真上から，すなわ ちt 細胞のtcr 側から見た模式図を図4 に The use of recombinant T cell receptors (TCRs) to target therapeutic interventions has been hindered by the naturally low affinity of TCR interactions with peptide major histocompatibility complex ligands. Here, we use multimeric forms of soluble heterodimeric αβ TCRs for specific detection of target cells pulsed with cognate peptide, discrimination of quantitative changes in antigen display |wsa| kbt| fpz| hqt| bpl| hvd| asl| ixh| ozw| xnx| jer| dlr| qgu| djm| xrg| oxo| rak| fmi| thj| slp| zap| qkg| tfu| mye| xeq| plj| rsi| bms| mmc| wke| vjz| ged| bbi| iqz| nxl| wbv| jrz| usw| xpp| ogi| uri| wgu| jms| vpe| hea| stz| rmj| hpw| vcv| fxj|