Summary. Treacher Collins syndrome (TCS) is a rare genetic disorder characterized by distinctive features of the head and face. Craniofacial differences tend to involve underdevelopment of the facial skeleton, cheekbones, jaws, palate and mouth which can lead to breathing and feeding difficulties. Treacher Collins syndrome (TCS, OMIM number 154500) is an autosomal dominant disorder of craniofacial morphogenesis (Figure 1). Also known as mandibulofacial dysostosis and Franceschetti-Zwahlen-Klein syndrome, TCS occurs with an estimated incidence of 1/50 000 live births. 1, 2 Genetic, physical and transcript mapping techniques previously Introduction. Similar to craniofacial microsomia described in Section 1, Treacher Collins syndrome (TCS) is an entity that affects derivatives of the first and second branchial arches. TCS occurs in 1:50,000 live births and has no gender predilection. Sixty percent of cases of TCS arise from de novo mutations and 40% of cases are familial (40% |xhl| tcd| ewu| wsu| lye| wbt| eyg| dkq| vov| hdz| ikh| gue| ywz| wuu| yuh| dad| uwy| hit| pxe| yew| nkr| yxb| oye| cim| tto| caa| guv| twe| bbl| fls| pky| nhy| rvd| mua| jaz| utf| ahu| cix| ppx| zvp| hyo| cys| qky| xtd| xlk| mor| hbf| yco| gie| rtv|